aparat aparat telegram1  ar en fa

ساعت کار مرکـز :

شنبه تا 4شنبه: ساعت 8 الی 22 - 5شنبه ها: ساعت 8 الی 14

instagram takipçi satın al indoXploit shell PUBG Lite

جدیدترین تکنیکها وروشهای درمانی درسرطان پستان

جدیدترین تکنیکها وروشهای درمانی درسرطان پستان جهت حفظ پستان بعداز عمل جراحی :

Identification and Resection of Clipped Node Decreases the False-negative Rate of Sentinel Lymph Node Surgery in Patients Presenting With Node-positive Breast Cancer (T0-T4, N1-N2) Who Receive Neoadjuvant Chemotherapy: Results From ACOSOG Z1071 (Alliance).
Boughey JC, et al. Ann Surg. 2016.
Show full citation

BACKGROUND: The American College of Surgeons Oncology Group Z1071 trial reported a false-negative rate (FNR) of 12.6% with sentinel lymph node (SLN) surgery after neoadjuvant chemotherapy in women presenting with node-positive breast cancer. One proposed method to decrease the FNR is clip placement in the positive node at initial diagnosis with confirmation of clipped node resection at surgery.

METHODS: Z1071 was a multi-institutional trial wherein women with clinical T0-T4,N1-N2,M0 breast cancer underwent SLN surgery and axillary dissection (ALND) after neoadjuvant chemotherapy. In cases with a clip placed in the node, the clip location at surgery (SLN or ALND) was evaluated.

RESULTS: A clip was placed at initial node biopsy in 203 patients. In the 170 (83.7%) patients with cN1 disease and at least 2 SLNs resected, clip location was confirmed in 141 cases. In 107 (75.9%) patients where the clipped node was within the SLN specimen, the FNR was 6.8% (confidence interval [CI]: 1.9%-16.5%). In 34 (24.1%) cases where the clipped node was in the ALND specimen, the FNR was 19.0% (CI: 5.4%-41.9%). In cases without a clip placed (n = 355) and in those where clipped node location was not confirmed at surgery (n = 29), the FNR was 13.4% and 14.3%, respectively.

CONCLUSIONS: Clip placement at diagnosis of node-positive disease with removal of the clipped node during SLN surgery reduces the FNR of SLN surgery after neoadjuvant chemotherapy. Clip placement in the biopsy-proven node at diagnosis and evaluation of resected specimens for the clipped node should be considered when conducting SLN surgery in this setting.

PMID 26649589 [PubMed - in process] PMCID PMC4777661 [Available on 2017-04-01]
Full text
Full text at journal site
Citation 8 of 436
Back to results Next
Similar articles

Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial.
Clinical trial
Boughey JC, et al. JAMA. 2013.
Axillary Ultrasound After Neoadjuvant Chemotherapy and Its Impact on Sentinel Lymph Node Surgery: Results From the American College of Surgeons Oncology Group Z1071 Trial (Alliance).
Clinical trial
Boughey JC, et al. J Clin Oncol. 2015.
Implementation of the american college of surgeons oncology group z1071 trial data in clinical practice: is there a way forward for sentinel lymph node dissection in clinically node-positive breast cancer patients treated with neoadjuvant chemotherapy?
Mittendorf EA, et al. Ann Surg Oncol. 2014.
Sentinel lymph nodes for breast carcinoma: an update on current practice.
Review article
Maguire A, et al. Histopathology. 2016.
Breast cancer sentinel node identification and classification after neoadjuvant chemotherapy-systematic review and meta analysis.
Review article
Kelly AM, et al. Acad Radiol. 2009.
See all
Full website NIH NLM NCBI Help

خواندن 1445 دفعه
شنبه, 04 ارديبهشت 1395 16:12 چاپ

نظرات (0)

تاکنون نظری برای این مطلب ارسال نشده است.

نظر خود را اضافه کنید.

در قالب میهمان نظر خود را ارسال کنید. ثبت نام کنید یا وارد شوید به حساب کاربریتان.
0 Characters
پیوست ها (0 / 3)
Share Your Location

اطلاعات مرکز

آدرس: اصفهان - خیابان شمس آبادی-چهارراه قصر-مجتمع قصرنور-طبقه 5-واحد501
تلفن‌های تماس: 32240047-031 - 09130748424
تلفن گویا: 9730361
فکس  : 03132240047
کدپستی: 3165844567
ایمیل: info@novintahlilgaran.com


رفتن به بالا