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Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome-wide shRNA screen.
Kurahara H, et al. Int J Cancer. 2016.
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Abstract

Therapeutic effectiveness against metastatic or even locally advanced pancreatic ductal adenocarcinoma (PDAC) is dismal, with 5-year survival less than 5%. Even in patients who undergo potentially curative resection, most patients' tumors recur in the liver. Improving therapies targeting or preventing liver metastases is crucial for improving prognosis. To identify genes suppressing metastasis, a genome-wide shRNA screen was done using the human non-metastatic PDAC cell line, S2-028. After identification of candidates, functional validation was done using intrasplenic and orthotopic injections in athymic mice. HMP19 strongly inhibited metastasis but also partially attenuated tumor growth in the pancreas. Knockdown of HMP19 increased localization of activated ERK1/2 in the nucleus, corresponding to facilitated cell proliferation, decreased p27(Kip1) and increased cyclin E1. Over-expression of HMP19 exerted the opposite effects. Using a tissue microarray of 84 human PDAC, patients with low expression of HMP19 showed significantly higher incidence of liver metastasis (P = 0.0175) and worse prognosis (P = 0.018) after surgery. HMP19, a new metastasis/tumor suppressor in PDAC, appears to alter signaling that leads to cell proliferation and appears to offer prognostic value in human PDAC. This article is protected by copyright. All rights reserved.

© 2016 UICC.
PMID 27012470 [PubMed - as supplied by publisher]
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new in breast cancer surgery

Breast cancer patients have fewer long-term side effects after partial radiotherapy.
[No authors listed] Nurs Stand. 2016.
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Abstract
Partial breast radiotherapy after surgery for cancer has fewer long-term side effects and is just as effective as standard whole breast radiotherapy, according to a new study.

PMID 27008124 [PubMed - in process]
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شنبه, 04 ارديبهشت 1395 15:31 چاپ

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