aparat aparat telegram1  ar en fa

ساعت کار مرکـز :

شنبه تا 4شنبه: ساعت 8 الی 22 - 5شنبه ها: ساعت 8 الی 14

instagram takipçi satın al indoXploit shell PUBG Lite

کاهش عوارض جانبی بعد از درمان تومور پستان

جدیدترین درمان در کاهش عوارض جانبی بعد از درمان تومور پستان:

Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome-wide shRNA screen.
Kurahara H, et al. Int J Cancer. 2016.
Show full citation

Therapeutic effectiveness against metastatic or even locally advanced pancreatic ductal adenocarcinoma (PDAC) is dismal, with 5-year survival less than 5%. Even in patients who undergo potentially curative resection, most patients' tumors recur in the liver. Improving therapies targeting or preventing liver metastases is crucial for improving prognosis. To identify genes suppressing metastasis, a genome-wide shRNA screen was done using the human non-metastatic PDAC cell line, S2-028. After identification of candidates, functional validation was done using intrasplenic and orthotopic injections in athymic mice. HMP19 strongly inhibited metastasis but also partially attenuated tumor growth in the pancreas. Knockdown of HMP19 increased localization of activated ERK1/2 in the nucleus, corresponding to facilitated cell proliferation, decreased p27(Kip1) and increased cyclin E1. Over-expression of HMP19 exerted the opposite effects. Using a tissue microarray of 84 human PDAC, patients with low expression of HMP19 showed significantly higher incidence of liver metastasis (P = 0.0175) and worse prognosis (P = 0.018) after surgery. HMP19, a new metastasis/tumor suppressor in PDAC, appears to alter signaling that leads to cell proliferation and appears to offer prognostic value in human PDAC. This article is protected by copyright. All rights reserved.

© 2016 UICC.
PMID 27012470 [PubMed - as supplied by publisher]
Full text
Full text at journal site
Citation 7 of 10084
Back to results Next
Similar articles

Nuclear expression of Y-box binding protein-1 is associated with poor prognosis in patients with pancreatic cancer and its knockdown inhibits tumor growth and metastasis in mice tumor models.
Shinkai K, et al. Int J Cancer. 2016.
Identification of ANXA1 as a lymphatic metastasis and poor prognostic factor in pancreatic ductal adenocarcinoma.
Liu QH, et al. Asian Pac J Cancer Prev. 2015.
SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma.
Mardin WA, et al. BMC Cancer. 2010.
Decreased TIP30 expression predicts poor prognosis in pancreatic cancer patients.
Guo S, et al. Int J Cancer. 2014.
The role of hyaluronan in pancreatic cancer biology and therapy: Once again in the spotlight.
Review article
Sato N, et al. Cancer Sci. 2016.
See all
Full website NIH NLM NCBI Help

new in breast cancer surgery

Breast cancer patients have fewer long-term side effects after partial radiotherapy.
[No authors listed] Nurs Stand. 2016.
Show full citation
Partial breast radiotherapy after surgery for cancer has fewer long-term side effects and is just as effective as standard whole breast radiotherapy, according to a new study.

PMID 27008124 [PubMed - in process]
Citation 9 of 10084
Back to results Next
Similar articles

Accelerated hypofractionated adjuvant whole breast radiotherapy with concomitant photon boost after conserving surgery for early stage breast cancer: a prospective evaluation on 463 patients.
Cante D, et al. Breast J. 2011.
The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials.
Randomized controlled trial
Haviland JS, et al. Lancet Oncol. 2013.
Fewer fractions of adjuvant external beam radiotherapy for early breast cancer are safe and effective and can now be the standard of care. Why the UK's NICE accepts fewer fractions as the standard of care for adjuvant radiotherapy in early breast cancer.
Review article
Harnett A, et al. Breast. 2010.
Breast-conserving surgery with intra-operative radiotherapy: the right approach for the 21st century?
Review article
Tobias JS, et al. Clin Oncol (R Coll Radiol). 2006.
Intraoperative radiotherapy (IORT) for breast cancer using the Intrabeam system.
Kraus-Tiefenbacher U, et al. Tumori. 2005.
See all
Full website NIH NLM NCBI Help

خواندن 1424 دفعه
شنبه, 04 ارديبهشت 1395 15:31 چاپ

نظرات (0)

تاکنون نظری برای این مطلب ارسال نشده است.

نظر خود را اضافه کنید.

در قالب میهمان نظر خود را ارسال کنید. ثبت نام کنید یا وارد شوید به حساب کاربریتان.
0 Characters
پیوست ها (0 / 3)
Share Your Location

اطلاعات مرکز

آدرس: اصفهان - خیابان شمس آبادی-چهارراه قصر-مجتمع قصرنور-طبقه 5-واحد501
تلفن‌های تماس: 32240047-031 - 09130748424
تلفن گویا: 9730361
فکس  : 03132240047
کدپستی: 3165844567
ایمیل: info@novintahlilgaran.com


رفتن به بالا