aparat aparat telegram1  ar en fa

ساعت کار مرکـز :

شنبه تا 4شنبه: ساعت 8 الی 22 - 5شنبه ها: ساعت 8 الی 14

جدیدترین ژنها در ایجادسرطان تیروئید

BLM, CBL, CIITA, EP300, GSTM5, LMO2, PRAME, SBDS, SF1, TET2, TNFAIP3, XPO1, and ZRSR2جدید ترین ژن ها در ایجاد سرطان تیروئید هستند:

Identification of Novel Oncogenic Mutations in Thyroid Cancer.
Pitt SC, et al. J Am Coll Surg. 2016.
Show full citation
Abstract
BACKGROUND: Thyroid cancer patients frequently have favorable outcomes. However, a small subset develops aggressive disease refractory to traditional treatments. Therefore, we sought to characterize oncogenic mutations in thyroid cancers to identify novel therapeutic targets that may

benefit patients with advanced, refractory disease.

STUDY DESIGN: Data on 239 thyroid cancer specimens collected between January 2009 and September 2014 were obtained from the Dana Farber/Brigham and Women's Cancer Center. The tumors were analyzed with the OncoMap-4 or OncoPanel high-throughput genotyping platforms that survey up to 275 cancer genes and 91 introns for DNA rearrangement.

RESULTS: Of the 239 thyroid cancer specimens, 128 (54%) had oncogenic mutations detected. These 128 tumors had 351 different mutations detected in 129 oncogenes or tumor suppressors. Examination of the 128 specimens demonstrated that 55% (n = 70) had 1 oncogenic mutation, and 45% (n = 48) had more than 1 mutation. The 351 oncogenic mutations were in papillary (85%), follicular (4%), medullary (7%), and anaplastic (4%) thyroid cancers. Analysis revealed that 2.3% (n = 3 genes) of the somatic gene mutations were novel. These included AR (n = 1), MPL (n = 2), and EXT2 (n = 1), which were present in 4 different papillary thyroid cancer specimens. New mutations were found in an additional 13 genes known to have altered protein expression in thyroid cancer: BLM, CBL, CIITA, EP300, GSTM5, LMO2, PRAME, SBDS, SF1, TET2, TNFAIP3, XPO1, and ZRSR2.

CONCLUSIONS: This analysis revealed that several previously unreported oncogenic gene mutations exist in thyroid cancers and may be targets for the development of future therapies. Further investigation into the role of these genes is warranted.

Copyright © 2016 American College of Surgeons. Published by Elsevier Inc. All rights reserved.
PMID 27010584 [PubMed - as supplied by publisher]
Full text
Full text at journal site
Previous
Citation 6 of 148443
Back to results Next
Full website NIH NLM NCBI Help

خواندن 1133 دفعه
چهارشنبه, 01 ارديبهشت 1395 17:16 چاپ

نظرات (0)

تاکنون نظری برای این مطلب ارسال نشده است.

نظر خود را اضافه کنید.

در قالب میهمان نظر خود را ارسال کنید. ثبت نام کنید یا وارد شوید به حساب کاربریتان.
0 Characters
پیوست ها (0 / 3)
Share Your Location

اطلاعات مرکز

آدرس: اصفهان - خیابان شمس آبادی-چهارراه قصر-مجتمع قصرنور-طبقه 5-واحد501
تلفن‌های تماس: 32240047-031 - 09130748424
تلفن گویا: 9730361
فکس  : 03132240047
کدپستی: 3165844567
ایمیل: info@novintahlilgaran.com

map

رفتن به بالا